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sivA [2017-05-12 17:44:32]
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sivA [2017-05-12 17:44:32]

inhibitor of KinA autophosphorylation, and subsequently of entry into sporulation
locus
BSU37800
pI
7.18
mw
16.55 kDa
protein length
154 aa Sequence Blast
gene length
462 bp Sequence Blast
function
control of entry into sporulation via the phosphorelay
product
inhibitor of KinA autophosphorylation
essential
no
synonyms
ipa-74d
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay] → [category|SW 3.4.7.2|Proteins controlling the activity of the kinases]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay] → [category|SW 4.2.2.2|Proteins controlling the activity of the kinases]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

    • Gene

    Coordinates
    3,882,191 → 3,882,655

    Phenotypes of a mutant

  • the'' [gene|E5E2994D96FCECEE75E15136A08308C7B6C1C183|sivA] [gene|E06A3392E644FEDC6F46ED41BBE89168F59B76B3|bslA]'' double mutant exhibits a more severe loss of repellency of the biofilm surface as compared to the ''[gene|E06A3392E644FEDC6F46ED41BBE89168F59B76B3|bslA]'' mutant [Pubmed|22571672]

    • The protein

    Catalyzed reaction/ biological activity

  • inhibits [protein|B29CAD04FB89ACC482EFCD29D50EDDA19145CAA2|KinA] autophophorylation [Pubmed|23335417]

    • Paralogous protein(s)

  • [protein|E06A3392E644FEDC6F46ED41BBE89168F59B76B3|BslA]

    • [SW|Localization]

  • membrane (according to Swiss-Prot)
  • extracellular (signal peptide) [Pubmed|18957862]

    • Expression and Regulation

    Operons

    genes
    [gene|E5E2994D96FCECEE75E15136A08308C7B6C1C183|sivA]
    description
    [Pubmed|12823818]

    regulatory mechanism

  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, [Pubmed|20817675], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]
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    Biological materials

    Mutant

  • MGNA-B238 (yweA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1237 NBRP B. subtilis, Japan]

    • References

  • 18957862,12823818,22571672,23335417,20817675